VISDB Viral Integration Site DataBase

VIS ID

TVIS10013348

Fusion event

HBV-RPH3A integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2189

Orient

-

Integrated sequence

GGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAA| |GTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCT

Chromosome

chr12

Cytoband

q24.13

Reference genome

Start

End

113319972/112882167 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA12E ; FRA12D

Target gene

miRNAs that regulate target gene

hsa-mir-106a-5p ; hsa-mir-7106-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-765 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-5197-3p ; hsa-mir-574-5p ; hsa-mir-493-5p ; hsa-mir-4666a-5p ; hsa-mir-6867-5p ; hsa-mir-3177-5p ; hsa-mir-124-5p ; hsa-mir-3650 ; hsa-mir-4455

Nearest miRNA

hsa-let-7i/Upstream/186991; hsa-mir-1178/Downstream/276946;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/306442, chr12-CpG: 37/Downstream/56213

Upstream sequence

ATCTGGGCAGCTGCCAATGCCAGAAGAGAAGCAGATGCCCTGATGATGCCCTTCATCTGCTCGAACACCTTCAGCGGCTCTCCCACTGCTGACTCTGGCT

Downstream sequence

CACCTCCCCTACACATTTTATGCCCCAACCACACACTCCTCATCTCTCAATAGAAATGAGTGGCTCTCTCCAAATTTTAGGACTAAGCACTTTGGAGAAT