Basic Information
VIS ID
TVIS10013365
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
168
Orient
+
Integrated sequence
CTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATC| |ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT
Host Sequence
Chromosome
chr19
Cytoband
q11
Reference genome
GRCh37/hg19
Start
27736723/27245815 (Hg38)
End
27736723/27245815 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/6846461; hsa-let-7e/Downstream/7876885;
Nearest TSS
ENST00000633603/Upstream/3099114; ENST00000588318/Downstream/394823;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3273858, chr19-CpG: 42/Downstream/547805
Nearby gene
LINC00662(+544678) ;
Upstream sequence
tatcttcgcataaaaactagacaaaatcattcccagaaactgcgtagtgatgtgtgtgtttatctcccagagtttaacctttcttttcataccgcattct
Downstream sequence
ggaaacactctgtttgtaaagtctgcaagtggatatttggacctcttagatgccttcgttggaaatgggatttcttcatataatgctagacagaagattt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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