MYO3B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013374
Fusion event
HBV-MYO3B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
+
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
171274934/170418424 (Hg38)
End
171274934/170418424 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
MYO3B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p
Nearest miRNA
hsa-mir-128-1/Upstream/1835406; hsa-mir-10b/Downstream/4749209;
Nearest TSS
ENST00000437798/Upstream/9860; ENST00000487037/Downstream/276950;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/590305, chr2-CpG: 44/Downstream/293388
Upstream sequence
TCTACATAACTAAGCTGAGTTAAAATGCATCTTTTTATTAGCAGAGGCATTATTGTATTAATATCATCGCTACTAAATTTTCTCTTTGCAAAACTAGAAT
Downstream sequence
TTTAAGCTGGAATCTGGAGAAGTGTGATTTCCCTGGAAAAGAGTTTGTAGACCTCTTTGTTTGTGAAAAGTGCATCCCTAGGTCTTCATAAAAGCTCTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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