Basic Information
VIS ID
TVIS10013382
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
301
Orient
+
Integrated sequence
CAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTC| |TTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCAT
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
53244638/52378472 (Hg38)
End
53244638/52378472 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/4725729; hsa-mir-1243/Downstream/334210;
Nearest TSS
ENST00000502981/Upstream/300128; ENST00000503051/Downstream/249894;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/301390, chr4-CpG: 141/Downstream/280325
Nearby gene
SPATA18(-281180) ; USP46(+212489) ;
Upstream sequence
atcccagctactctggaggctgaggcacgagaatcactggaacccaggaggcagatgttgtagtaagccaagatggtgccattgcactccagcctgggtg
Downstream sequence
acctgaccattgaaagaaaaagaaacaaacagaaagcaacaacagcagcatcaacaacaataacaaaaaaaaaaaacccataaaaaccccatccaaggat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate