Basic Information
VIS ID
TVIS10013385
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
257
Orient
+
Integrated sequence
TGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTC| |GTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCA
Host Sequence
Chromosome
chr4
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68265531/67399813 (Hg38)
End
68265531/67399813 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1122885; hsa-mir-1243/Downstream/9173755;
Nearest TSS
ENST00000502981/Upstream/1396532; ENST00000265404/Downstream/21241;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1728857, chr4-CpG: 37/Downstream/145462
Nearby gene
EPHA5-AS1(-1706427) ; CENPC(+72458) ;
Upstream sequence
ATTAAAATATTTTGTGTAATTTATGATATCTCATCTTTAGAATAAAAATGCTACTTAGGAGCTTTCTTTTTAAAATTCAGGAATTGCTTAGTTCCTAAAC
Downstream sequence
ccattggcctcaaagcgattgaaatttccacatggaaattccacaaaaagagtgtttcaaatctgctctgtctaaaggaaagttcaactctgtgagttga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate