Basic Information
VIS ID
TVIS10013394
Fusion event
HBV-LINC00824 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1621
Orient
+
Integrated sequence
CGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACC| |GTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTT
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
129524908/128512662 (Hg38)
End
129524908/128512662 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC00824
Nearest miRNA
hsa-mir-1204/Upstream/362474; hsa-mir-10400/Downstream/971395;
Nearest TSS
ENST00000518652/Upstream/416143; ENST00000519048/Downstream/453339;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/662684, chr8-CpG: 122/Downstream/1426464
Nearby gene
MIR1208(-362474) ; LINC00977(+703805) ;
Upstream sequence
tggagataagtatcagtagccataactaaaataggtgagaaggaccagtacagtggctcacgcctgtaatcctagcactttgggaggccaaggtgggcag
Downstream sequence
TCTGCTTTTCCCCACTTTCTAGAACACTGTGCAAAAATAGAGGCACTGTCTGGTTGATTATATACCTCATTTGCCAGTCCTGGTAAATTGGACTGTCTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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