Basic Information
VIS ID
TVIS10013402
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1858
Orient
+
Integrated sequence
GTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTC| |CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
12107392/12047335 (Hg38)
End
12107392/12047335 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/18113; hsa-mir-101-1/Downstream/119608;
Nearest TSS
ENST00000473358/Upstream/16208; ENST00000514649/Downstream/16042;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/27489, chr1-CpG: 63/Downstream/16096
Nearby gene
MIIP(-15286) ; TNFRSF8(+16042) ;
Upstream sequence
TGcacatgcatacacacacgcacacacacacgcacacacacacatgcacacacacacatgcacacacacacGTGCTGCAGGAAGCCCTGTCATTGTCAGT
Downstream sequence
GTGGCCCCAGAACTTAGTCATTTAATGACCCATTGGGCCGTGTTTCTTTCATGGAAGCCAACACTTGGCTTTTTCTTTACCGAGATCTTCTCACTCAGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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