Basic Information
VIS ID
TVIS10013422
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
382
Orient
+
Integrated sequence
GGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGT| |GTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCT
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
77170540/76704855 (Hg38)
End
77170540/76704855 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/5637139; hsa-mir-11399/Downstream/355288;
Nearest TSS
ENST00000473358/Upstream/67978; ENST00000496845/Downstream/74412;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/907637, chr1-CpG: 112/Downstream/162571
Nearby gene
ST6GALNAC3(-73871) ; ST6GALNAC5(+162646) ;
Upstream sequence
TCTGTCAATAATCAACAAAGCCTCACTACTTATTCATAAAGAGCCATGTTTTTTTAAATTATATGCATTCTCTAAGAATTATGCTGATATCACTCTATTG
Downstream sequence
ATAGCTGCATTTATAAGCCAATTCAAAATCCAAAATATTTGCCTCAGATGTTAACTACAAGGAGTACATATTCATAGAGATATGTTGCTGCGGCATAATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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