VISDB Viral Integration Site DataBase

VIS ID

TVIS10013427

Fusion event

HBV-PDE3B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1823

Orient

-

Integrated sequence

TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA

Chromosome

chr11

Cytoband

p15.2

Reference genome

Start

End

14702684/14681138 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-93-5p ; hsa-mir-16-5p ; hsa-mir-562 ; hsa-mir-3119 ; hsa-mir-4735-5p ; hsa-mir-5683

Nearest miRNA

hsa-mir-210/Upstream/2517371; hsa-let-7a-2/Downstream/1288395;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/36010, chr11-CpG: 68/Downstream/210216

Upstream sequence

CAGTATTCTCACCAGTCAAAACCAGACTTTCAATTTATGGTATTTTCACCAGTGAAAAGCACACTTTTGACTTAATATTTTCAAACCAGTGAAAAGCACA

Downstream sequence

TTTTTGACTTAATATTTTTATCAGTTGAAAGCAcactttcaaattgtgatattttcaacttatagtgcatttatctagacataacctcattgtaagtcga