DACH1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013441
Fusion event
HBV-DACH1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1837
Orient
+
Integrated sequence
GGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCC| |TAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTAC
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
72107498/71533366 (Hg38)
End
72107498/71533366 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
DACH1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-217
Nearest miRNA
hsa-mir-1297/Upstream/5315042; hsa-mir-1267/Downstream/6164646;
Nearest TSS
ENST00000623511/Upstream/518225; ENST00000618209/Downstream/333403;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1425279, chr13-CpG: 62/Downstream/331864
Nearest cancer related gene
DACH1(TSG, No orient, 0)
Upstream sequence
CATTTCCCTATTTTTCATTTGGAAGTCAGCTTTCAAGGAAATAAAAAAGTTTCATAAGTAATTCCTCGTATTTTCAATCTAAAGATCAGCATGAGAAAAG
Downstream sequence
GAAAGGAAACGTGACAGTGAAATTTATATCTTTTAGGACAAAACTCCAAGCTTGGCTGTTACTTATTTGCCTAATTTTCCTCAGTGGCTTAAATTAGGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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