Basic Information
VIS ID
TVIS10013443
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1903
Orient
+
Integrated sequence
CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA| |TGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGC
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
87194481/86542226 (Hg38)
End
87194481/86542226 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/8844110; hsa-mir-1267/Downstream/1076439;
Nearest TSS
ENST00000623511/Upstream/481413; ENST00000609962/Downstream/367360;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/2662464, chr13-CpG: 121/Downstream/1129088
Nearby gene
SLITRK6(-820998) ; MIR4500HG(+901761) ;
Upstream sequence
GCTTAATTTCTTTTTACTTCCATACCATTTAGAAAGTTCAGTTCCTggccgggtgcagtggctcacgcctgtaatcccagtactttgggaggccgaggag
Downstream sequence
ggcggatcacgaggtcaggaaatcgagaccatcctggctaacatggtgaaaccccgtctctactaaaaatacaaaaacaaaattagccgggtgtgttggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate