Basic Information
VIS ID
TVIS10013445
Fusion event
HBV-TTC6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2060
Orient
+
Integrated sequence
CTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATAC| |TGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTC
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
38146774/37677569 (Hg38)
End
38146774/37677569 (Hg38)
Orient
+
Location type
Intronic
Target gene
TTC6
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-208a/Upstream/725178; hsa-mir-1185-1/Downstream/10083426;
Nearest TSS
ENST00000550708/Upstream/55504; ENST00000554555/Downstream/94814;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/54598, chr14-CpG: 43/Downstream/530380
Nearby gene
FOXA1(-82449) ; SSTR1(+530430) ;
Upstream sequence
tgtaatcatattcatttgcaaataaagagatttttTATAATTAGTGGTTTTTATTATTCTGACAGTGAActtggggcagtgttctttgtgtgtttctgct
Downstream sequence
cagaggtcattgaacttagggggtttgtagctgtcatgatatttggaaaatttttggccatttgtgtgtgaatattttcagtcactccccatatcccttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate