VISDB Viral Integration Site DataBase

VIS ID

TVIS10013449

Fusion event

HBV-VPS35 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1822

Orient

+

Integrated sequence

GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA

Chromosome

chr16

Cytoband

q11.2

Reference genome

Start

End

46693377/46659465 (Hg38)

Orient

+

Location type

downstream

Target gene

miRNAs that regulate target gene

hsa-mir-590-3p ; hsa-mir-27a-3p ; hsa-mir-24-3p ; hsa-mir-342-3p ; hsa-mir-15b-5p ; hsa-mir-4459 ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-1273e ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-25-5p ; hsa-mir-658 ; hsa-mir-4722-5p ; hsa-mir-6087 ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-4649-3p ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-302f ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-4668-5p ; hsa-mir-3153 ; hsa-mir-5680 ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-1203 ; hsa-mir-3140-5p ; hsa-mir-3659 ; hsa-mir-3689d ; hsa-mir-4658 ; hsa-mir-4669 ; hsa-mir-4731-5p ; hsa-mir-493-3p ; hsa-mir-5589-5p ; hsa-mir-574-5p ; hsa-mir-6790-5p ; hsa-mir-6851-5p

Nearest miRNA

hsa-mir-1225/Upstream/12495792; hsa-mir-11401/Downstream/3633151;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/38003, chr16-CpG: 129/Downstream/29187

Upstream sequence

ataaatgtttgctgttttaagacagtaagttttgggatggtttattatatagtaggtaactagtaTCGGTGGTGAGCCTTTGGGGGGTTTATGTGAATTC

Downstream sequence

ATCATGCCTTGGGAAAAGCAGGGTAAAGTTGAGGAAAGAAAAGGGGTATAAATGACTAAAAGAGTAGATGCTGCCTTGTTCAACAAGTGCTTAAAACTAG