Basic Information
VIS ID
TVIS10013473
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2744
Orient
-
Integrated sequence
GCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGAC| |ACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCT
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
59148781/58282615 (Hg38)
End
59148781/58282615 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4B
Nearest miRNA
hsa-mir-12113/Upstream/5569868; hsa-mir-1243/Downstream/2640004;
Nearest TSS
ENST00000502981/Upstream/562580; ENST00000513836/Downstream/253713;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1086666, chr4-CpG: 222/Downstream/2917550
Nearby gene
IGFBP7-AS1(-1077316) ;
Upstream sequence
atatctacccaaagggaaataagtcattacatcaaaaagacacctacatgcatctgtttattgcagcacaatttcaaagatatggaaccaatctaagtac
Downstream sequence
ccagtctcaggtacgtctttattagcagcatgagaacagactaatacagccagtttagagagaatttcttccctccatatctgattaaatttctcattct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate