Basic Information
VIS ID
TVIS10013483
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1796
Orient
-
Integrated sequence
CTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAAT| |TGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTT
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
111955231/111634028 (Hg38)
End
111955231/111634028 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6F
Nearest miRNA
hsa-mir-10398/Upstream/4849808; hsa-mir-1202/Downstream/7435019;
Nearest TSS
ENST00000381078/Upstream/27750; ENST00000483439/Downstream/42516;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/149722, chr6-CpG: 116/Downstream/238604
Nearby gene
TRAF3IP2(-27754) ; FYN(+26304) ;
Nearest cancer related gene
FYN(OG, +26304) ;
Upstream sequence
ttcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaatcaatagaaaaagagggaatcctccctaactcat
Downstream sequence
tgttatgaatatacttattctgaatattcatgtacaagtctttttgtaagcatatgtactgttttctcttggatgtatacctgggagtggagttgatggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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