Basic Information
VIS ID
TVIS10013493
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2306
Orient
-
Integrated sequence
GGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACC| |AAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCT
Host Sequence
Chromosome
chr9
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
114119253/111356973 (Hg38)
End
114119253/111356973 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA9E
Nearest miRNA
hsa-let-7a-1/Upstream/85759; hsa-mir-12126/Downstream/575127;
Nearest TSS
ENST00000422679/Upstream/26790; ENST00000374374/Downstream/13631;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/317878, chr9-CpG: 230/Downstream/125791
Nearby gene
OR2K2(-28540) ; ECPAS(+3720) ;
Upstream sequence
tttattttattttttgtagacacagggtttcactatgttgcctgggctgttctcaacctcctgggctcaagtgatccacccgcctcagcctcccaaagtg
Downstream sequence
actgcctgctcaaattgaaaagcagctctttggaggaacagtccagagtctccacgacataacatgcacaatgtctaagaatgttgggttacagtcccaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate