Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013497
Fusion event
HBV-FHL1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
1938
Orient
+
Integrated sequence
AATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACT| |GTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTG
Host Sequence
Chromosome
chrX
Cytoband
q26.3
Reference genome
End
135265861/136183702 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7f-2/Upstream/1636991; hsa-mir-105-1/Downstream/367176;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/35812, chrX-CpG: 88/Downstream/67175
Nearest cancer related gene
FHL1(TSG, No orient, 0)
Upstream sequence
cagtgttcattaaggatattggtctaaaattctcttttttggtttgtctccgccaggctttggtatcaggatgacgctggcctcataaaatgagttaggg
Downstream sequence
CCTGCAAAATGTATGTTTAAAATACATAAAAATTGATGGGACCATGTACTTATGGCTAGTCGGAAAGTGGAAAGTTTTTTAGATTTATGCTTAGGACAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.