Basic Information
VIS ID
TVIS10013501
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
637
Orient
-
Integrated sequence
GCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAAT| |TCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGT
Host Sequence
Chromosome
chr1
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
121353223/121611425 (Hg38)
End
121353223/121611425 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4516697; hsa-mir-1182/Downstream/24239162;
Nearest TSS
ENST00000473358/Upstream/30901; ENST00000443018/Downstream/21889087;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/91698, chr1-CpG: 312/Downstream/3474084
Nearby gene
EMBP1(-39537) ;
Upstream sequence
ctcacaaagaagtttctgagaatgcttctgtttattttttatgtgaagatattcccgtttccaaagaaatcttcacagaggtccacatatccacttgcag
Downstream sequence
attctacaaaaagagagtttcaaaactgctgtatcaaaaggaatgttcaactctgcgagttgaatgcaatcatcacaaagcagtttctgagaaggcttcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate