Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013510
Fusion event
HBV-EIF3L integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|
Start
3172
Orient
+
Integrated sequence
AAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGC| |CATGCAGTGG
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
Start
End
38274778/37878771 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-769-3p ; hsa-mir-340-3p ; hsa-mir-320a ; hsa-mir-7-5p ; hsa-mir-19b-3p ; hsa-mir-665 ; hsa-mir-7150 ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-873-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-4768-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-3914 ; hsa-mir-7851-3p ; hsa-mir-5197-5p ; hsa-mir-490-3p
Nearest miRNA
hsa-mir-1286/Upstream/30997; hsa-let-7a-3/Downstream/88792;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/29097, chr22-CpG: 98/Downstream/27176
Upstream sequence
agtctggtgtcaaactcccaacctcaggtgatcagccagccttggcctcccaaagtgctgggattaccaacaatagatgttataattaaacaatagatgt
Downstream sequence
tataattaaacaaactatgtagtaagaagttgccaagcactgcagagtaaaggaaggcagaggtggtgggaagcacaggttgcaatgttaaatacggtgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.