VISDB Viral Integration Site DataBase

VIS ID

TVIS10013514

Fusion event

HBV-POLR2B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

133

Orient

-

Integrated sequence

CCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGA| |GGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCT

Chromosome

chr4

Cytoband

q12

Reference genome

Start

End

57869988/57003822 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-30a-5p ; hsa-mir-455-3p ; hsa-mir-615-3p

Nearest miRNA

hsa-mir-12113/Upstream/4291075; hsa-mir-1243/Downstream/3918797;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/24786, chr4-CpG: 124/Downstream/105872

Upstream sequence

tgataggagcaccaaccctattataaactgcatgtggaagtgatctaggttgtgtgctccttatgagaatctaatgcctgatgatctgtcactgtttccc

Downstream sequence

acaaagggagactgactgtgtctcttaaaaaaaaaaagaaaaagaagaagaagaaatagttgggtgtggtggtgttgtctgtactcctcctagctaccac