Basic Information
VIS ID
TVIS10013522
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
249093208/248799009 (Hg38)
End
249093208/248799009 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1I
Nearest miRNA
hsa-mir-101-1/Upstream/1596949; hsa-mir-3124/Downstream/27368;
Nearest TSS
ENST00000473358/Upstream/43270; ENST00000515369/Downstream/15164;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/50733, chr1-CpG: 43/Downstream/12887
Nearby gene
LYPD8(-190057) ; SH3BP5L(+11443) ;
Upstream sequence
aggtatctcatgtaagttgaatcatacaatatttgtcttttgtgactggcacatttcacttagcataacttcctcaagttagtcattgacttcttatgtt
Downstream sequence
agtcttgtatcccatgaccttgcaatgctaacttacttccataaattggtttgttttgtttgtcaattctttgagatgttctacatagaaaattgtatct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate