VISDB Viral Integration Site DataBase

VIS ID

TVIS10013528

Fusion event

HBV-PTPN11 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1822

Orient

-

Integrated sequence

GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA

Chromosome

chr12

Cytoband

q24.13

Reference genome

Start

End

112909232/112471428 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA12E ; FRA12D

Target gene

miRNAs that regulate target gene

hsa-mir-489-3p ; hsa-mir-181a-5p ; hsa-mir-23a-3p ; hsa-mir-124-3p ; hsa-mir-218-5p ; hsa-mir-130b-5p ; hsa-mir-193b-3p ; hsa-mir-320a ; hsa-mir-183-5p ; hsa-mir-6826-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-942-5p ; hsa-mir-6870-3p ; hsa-mir-6793-3p ; hsa-mir-6729-3p

Nearest miRNA

hsa-let-7i/Upstream/308107; hsa-mir-1178/Downstream/223606;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/51989, chr12-CpG: 52/Downstream/103789

Nearest cancer related gene

PTPN11(OG, No orient, 0)

Upstream sequence

CCCATTAAACACTAGGCTTTTTGTAAACCAATTATCCCTTGAAATTGACtttttttttttttgagacaggatcttgttttgccacacaggctggagtgcc

Downstream sequence

gtggctccatcataTGATAAACagaaagagagagagagagagagagagagagagagagagagaCCCTGTCTTATTTAAAACAAAAAAAGAAGAAGAAAAA