NAV3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013529
Fusion event
HBV-NAV3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1944
Orient
+
Integrated sequence
CTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAG| |TTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATT
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
78305574/77911794 (Hg38)
End
78305574/77911794 (Hg38)
Orient
+
Location type
Intronic
Target gene
NAV3
miRNAs that regulate target gene
hsa-mir-29a-3p ; hsa-mir-21-5p
Nearest miRNA
hsa-let-7i/Upstream/8326971; hsa-mir-1178/Downstream/1507463;
Nearest TSS
ENST00000382841/Upstream/80505; ENST00000551277/Downstream/28473;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/845632, chr12-CpG: 38/Downstream/892490
Upstream sequence
ATGTATTCGAAGGATCAATTATTTATAGTACCCTatgtgaatttttcattttatgaccaaatgtgtttattttagtctaaaattaatgttttaaatcatt
Downstream sequence
gtcattaaactaattttcaagcaagttgagccacgctaattagaaatattcttataccactgatcatatattttttttaactccagggtgttcagacccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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