Basic Information
VIS ID
TVIS10013533
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1637
Orient
-
Integrated sequence
TTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAA| |TATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGA
Host Sequence
Chromosome
chr13
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
54678556/54104421 (Hg38)
End
54678556/54104421 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-15a/Upstream/1294281; hsa-mir-1267/Downstream/207551;
Nearest TSS
ENST00000623511/Upstream/289002; ENST00000616396/Downstream/22922;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/902211, chr13-CpG: 25/Downstream/3036416
Nearby gene
LINC00558(-228302) ; MIR1297(+207551) ;
Nearest cancer related gene
MIR1297(TSG, +207551) ;
Upstream sequence
ccaaaacaattagaatagttacatctgatcacagattaccataacagatataataatagtaaaaatttgaaatattgtcaaaatgtgacacagaaacaag
Downstream sequence
aagtgagcacatgatgtcataaaaatggcattaatagcaggattgcaatgagctgatagctcaaagcaggattgccataaacatttgatttgtagaaact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate