Basic Information
VIS ID
TVIS10013534
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2276
Orient
+
Integrated sequence
ATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTG| |GATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGA
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
76974744/76508401 (Hg38)
End
76974744/76508401 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/2028197; hsa-mir-1185-1/Downstream/757817;
Nearest TSS
ENST00000550708/Upstream/8755; ENST00000554237/Downstream/218311;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/16670, chr14-CpG: 135/Downstream/252825
Nearby gene
ESRRB(-6564) ; VASH1(+253491) ;
Nearest cancer related gene
ESRRB(TSG, -6564) ;
Upstream sequence
CATTCATCATCTGGCACAGGGCTAGATTTGCGGGGTATGGTGGGAGCTCAGAGTCCAGCAGGGAAGGTAAACATTGAACTAGTGGTTCACGAGTGTATTT
Downstream sequence
TATTACAGGAGACTTTTAGCAATATAAGAGAGACTTTAATGGAGGCAGGCACCAACCTGGCCTTTAGTGGTAGGGATGGTGAAGAACAGTTGTCCAAGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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