Basic Information
VIS ID
TVIS10013535
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1836
Orient
+
Integrated sequence
AGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGC| |CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
37440098/37147897 (Hg38)
End
37440098/37147897 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1233-1/Upstream/174996; hsa-mir-10393/Downstream/4543688;
Nearest TSS
ENST00000557528/Upstream/38310; ENST00000560841/Downstream/342911;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/36831, chr15-CpG: 21/Downstream/342786
Nearby gene
MEIS2(-46598) ; TMCO5A(+787359) ;
Upstream sequence
TATTACCTTTAAAATTGTTAGGTTGAAATAAACACTATGGTTTTTGGGGTCATTCTTTCTCTCTTTTTTCTTTTTAAATGAATTCCCCCCATGAATAATT
Downstream sequence
TTTTTATTTCGGTATTTTCATTGTAATCAAGGTTATAATTGACAGCTTTATAATACCAGGGGGCACAGTTGAGGTCTCTTTCGCTTTTCAAACATTCTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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