VISDB Viral Integration Site DataBase

VIS ID

TVIS10013537

Fusion event

HBV-HOMER2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1826

Orient

-

Integrated sequence

AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA

Chromosome

chr15

Cytoband

q25.2

Reference genome

Start

End

83612798/82944046 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-103a-2-5p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-4291 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-922 ; hsa-mir-5007-5p

Nearest miRNA

hsa-mir-10393/Upstream/1946573; hsa-mir-11181/Downstream/123289;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/133525, chr15-CpG: 108/Downstream/8152

Nearest cancer related gene

HOMER2(TSG, No orient, 0)

Upstream sequence

CCTCATCCTAAGCTTGTCTGCACAGGGGTGGGGACTCTACCATCTCCAATTCCTCAGAGGAATAATAATAAGACTATCAACCAGGCTTATGaataaaaat

Downstream sequence

tttttttttaaatCTCTCTAGTCTTTGACAAATGTCTAAATGTGTTCCCCACAAGCATATTTTTATTCTAACAAGCTAATTTGAAATATAATTTAAATAA