Basic Information
VIS ID
TVIS10013541
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1298378/1248377 (Hg38)
End
1298378/1248377 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3176/Upstream/478100; hsa-mir-11401/Downstream/486608;
Nearest TSS
ENST00000527434/Upstream/7126; ENST00000397534/Downstream/7682;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/29772, chr16-CpG: 26/Downstream/9626
Nearby gene
TPSAB1(-5823) ; TPSD1(+7895) ;
Upstream sequence
atgcacacacacatgcacacacacgcacatctgtgcactcacatgcacatatgcacacacggatgttcacatgcacacacgaacacatgcacacattcac
Downstream sequence
acacacacatgcacactcacacaggcacactcacacactgacacacacacactcccacgtgcacatctacacggccatatctataatgaaaaccatgagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate