Basic Information
VIS ID
TVIS10013542
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1298452/1248451 (Hg38)
End
1298452/1248451 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3176/Upstream/478174; hsa-mir-11401/Downstream/486534;
Nearest TSS
ENST00000527434/Upstream/7200; ENST00000397534/Downstream/7608;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/29846, chr16-CpG: 26/Downstream/9552
Nearby gene
TPSAB1(-5897) ; TPSD1(+7821) ;
Upstream sequence
acacacgaacacatgcacacattcacacacacacatgcacactcacacaggcacactcacacactgacacacacacactcccacgtgcacatctacacgg
Downstream sequence
ccatatctataatgaaaaccatgagctctcacagtgcctcagctgtgattccaccccacagggcttactctgcgtttctcttctcccatcgggctgcctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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