Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013546
Fusion event
HBV-CCDC57 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
1955
Orient
+
Integrated sequence
GTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTT| |TTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCAC
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
Start
End
80109327/82151451 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10226/Upstream/457582; hsa-mir-4525/Downstream/85217;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/23994, chr17-CpG: 119/Downstream/60995
Upstream sequence
GAACCTGGCACACACCCAGAACCTGGCACACACCCAGAACCTGACCCACACCCAGAACCTGGCGCACCCCCAGAATCTGACCCACATCCAGAACCTGGTG
Downstream sequence
CACCCCCAGAATCTGACCCACATCCAGAACCTGGCGCACACCCAGAACCAGGTGCACACCCAGAACCTGACCCACACTCAGGCCATGGCCTCCACTTCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.