MAPK4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013548
Fusion event
HBV-MAPK4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2033
Orient
+
Integrated sequence
CTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTC| |TCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAA
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
48157545/50631175 (Hg38)
End
48157545/50631175 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAPK4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-127-3p
Nearest miRNA
hsa-mir-1-2/Upstream/504612; hsa-mir-122/Downstream/2605926;
Nearest TSS
ENST00000575820/Upstream/1757; ENST00000587823/Downstream/33124;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/69956, chr18-CpG: 21/Downstream/32889
Upstream sequence
cgcctgacatgcacattcccggccgaggtcagacagggtgacacgctgccttctggtttcagctctcatactgcaaacaagtgtcttcgcagtctattta
Downstream sequence
gtgccacttttttttgttttgcatttttgtgcttttttgttgatggtgatattgcagttctgaaatggctccttaagcatagcgctgaggtgctatctag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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