Basic Information
VIS ID
TVIS10013549
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1754
Orient
-
Integrated sequence
CATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGA| |TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
5705762/5705763 (Hg38)
End
5705762/5705763 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-6718/Upstream/1820331; hsa-mir-1-2/Downstream/134932;
Nearest TSS
ENST00000575820/Upstream/75063; ENST00000580378/Downstream/43056;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/74977, chr18-CpG: 131/Downstream/184530
Nearby gene
EPB41L3(-161776) ; MIR3976HG(+43056) ;
Nearest cancer related gene
EPB41L3(TSG, -161776) ;
Upstream sequence
CATGGCCATTGAGCTTGTTGAGCTAATTTCTTTTGTCCTTCTCCAGTCCCAGGCTCTGTGGCTACATCTGATTTCTCCAGCCCCTGCCATACCCATCCCC
Downstream sequence
AGGTAACTGGCCTCTGCCCAACCCCACTTGGCTCCTCTTTTCTGTCACTGATGGTGACATGAACTTGGTCTGTGAGATCGGGGTTGGGGggtgaagagct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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