Basic Information
VIS ID
TVIS10013551
Fusion event
HBV-LINC01961 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1789
Orient
-
Integrated sequence
GACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGG| |CATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGG
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
114263273/113505696 (Hg38)
End
114263273/113505696 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
LINC01961
Nearest miRNA
hsa-mir-1285-2/Upstream/1734562; hsa-mir-10b/Downstream/77263;
Nearest TSS
ENST00000437798/Upstream/7031; ENST00000449954/Downstream/6767;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1479, chr2-CpG: 122/Downstream/35762
Nearby gene
FOXD4L1(-4546) ; FAM138B(+71686) ;
Upstream sequence
tttgaattagaatgctaataagggttacgtattgtgtttggttgatatgggctattatatctcttttagatttcctcaatcctctttttttgtttccctt
Downstream sequence
gcattttttatgggagaaactgaactgtttgttctgaagaagctgacattctggactttgTAGCTGCAGGTAATAGTTTTTTGGCAAGATATTCCCAGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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