Basic Information
VIS ID
TVIS10013554
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2297
Orient
+
Integrated sequence
AACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTA| |TAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGA
Host Sequence
Chromosome
chr2
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
121318728/120561152 (Hg38)
End
121318728/120561152 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/6839784; hsa-mir-10b/Downstream/6862385;
Nearest TSS
ENST00000437798/Upstream/3043; ENST00000418323/Downstream/149313;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/38545, chr2-CpG: 44/Downstream/15580
Nearby gene
LINC01101(-94803) ; GLI2(+236139) ;
Nearest cancer related gene
GLI2(OG, +236139) ;
Upstream sequence
cccaggtccttggaccccATTTGAGCCCCTTACATGGGTGTGGACCTTCTGCCCAGCCAAAGTGACTCAGAACTGTGGCCCTGAGGTGTTTCTGAGGAGG
Downstream sequence
GATGAGGCGGGATGGTGGAGGAGCCAAGGGCTCATCCCTCAGCTGCAAAGGCTGCAAGGACCCTTTAAGGCCTTCCACCAGGACCTCCTGACGATGGAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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