Basic Information
VIS ID
TVIS10013557
Fusion event
HBV-LOC105377632 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
633
Orient
-
Integrated sequence
TACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGA| |AAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTT
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
End
57726425/57499290 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-1301/Upstream/1498495; hsa-mir-10b/Downstream/2888072;
Nearby gene
CCDC85A(-1113116) ; VRK2(+547352) ;
Upstream sequence
ACAAAAATTGTCATTCATACACCCCGTCTACATGCATACCTATTGTGCATACAATTCCACAAGGAAAACAATATGAATAATATAATGTAAATACCTTGAA
Downstream sequence
GAGAAGTCAATTTCACTGAGAATATTTGGATTCTATGACTGTTACCAATTTGGCTTGATTCACCGTAGATACTAAGTGTTGCCTACTTCCCTTCAAAAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate