Basic Information
VIS ID
TVIS10013566
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1766
Orient
-
Integrated sequence
CTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGG| |TCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTT
Host Sequence
Chromosome
chr3
Cytoband
p23
Reference genome
GRCh37/hg19
Start
31197394/31155902 (Hg38)
End
31197394/31155902 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/5490963; hsa-let-7g/Downstream/5802;
Nearest TSS
ENST00000440867/Upstream/261137; ENST00000462235/Downstream/376736;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/261129, chr3-CpG: 196/Downstream/375908
Nearby gene
GADL1(-261241) ; STT3B(+377097) ;
Upstream sequence
CACCACACAGAACAAGGCAAAGGCTGATTACGAGAGCAAAATATGTAGCACCCAGTGTCCACAGGTGTGTTTACAGAACTGCTGCTGTGATTATCGTCAT
Downstream sequence
AAGTGGCTGCTTTGCAGAGCTCCATGGGGCAGTATTCCCAAATCTAAACAATAGATGCCGGAGAGCCAATCGACACAAGTAATTTATTGTGGGTCCCTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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