Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013572
Fusion event
HBV-SLCO6A1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2359
Orient
+
Integrated sequence
GTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAG| |GCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTC
Host Sequence
Chromosome
chr5
Cytoband
q21.1
Reference genome
End
101743969/102408265 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10397/Upstream/1591700; hsa-mir-103a-1/Downstream/8105564;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/111596, chr5-CpG: 32/Downstream/90385
Upstream sequence
tctggccccagccatctctccagcctcatttctgGTGACTCCCAGATCTGGCCCCAGCCATGTCTCTAGACTCCAAACTTATTCCTTATAATGCTCCCAC
Downstream sequence
caaaataccttaatattttcagaccacagttgattgcaggtcatttaaattatggaTGCAGGGGCTACTGTAATTTATTATGTAGCAATAATAAACTAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.