Basic Information
VIS ID
TVIS10013573
Fusion event
HBV-FAXDC2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2045
Orient
+
Integrated sequence
TACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTG| |TTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCT
Host Sequence
Chromosome
chr5
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
154198558/154818998 (Hg38)
End
154198558/154818998 (Hg38)
Orient
+
Location type
UTR3
Target gene
FAXDC2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-10397/Upstream/133137; hsa-mir-103a-1/Downstream/10460;
Nearest TSS
ENST00000502646/Upstream/7610; ENST00000518782/Downstream/5710;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/61549, chr5-CpG: 124/Downstream/38450
Upstream sequence
ttcacagccgaattctaccagaggtacaaggaggagctggtaccattccttctgaaactattccaataaatagaaaaagagggaatcctccctaactcat
Downstream sequence
CTACTGGGCAAGTCCTCTGGGGTTCTAGAGCTGATAGGAAGAAGGAGTCCATTTTGATAGTCCTGCCTGGAGACTTGGACCTAGCTGATACTAAGGTATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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