Basic Information
VIS ID
TVIS10013582
Fusion event
HBV-LINC00689 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1838
Orient
+
Integrated sequence
GAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCT| |AATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACT
Host Sequence
Chromosome
chr7
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
158802144/159009453 (Hg38)
End
158802144/159009453 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA7I
Target gene
LINC00689
Nearest miRNA
hsa-mir-10399/Upstream/417757;
Nearest TSS
ENST00000635602/Upstream/75260; ENST00000377633/Downstream/87751;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2710, chr7-CpG: 23/Downstream/13948
Upstream sequence
aaagtgctgggattacaggcgtgagccaccgtgcctggccCAATCTGATAAATTTATTAGATAATTCAAGACATCTGTGTACGCCACTGTTTCACAAAGT
Downstream sequence
CTGTATCCGTTTTCTTAAGCTGTAGGCTCACAATATCAAGGGCTCTGTGTGAAGACTTGGGTGGTTACAGAGGTGCCACCAAGTGGATGGGTCACATGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate