Basic Information
VIS ID
TVIS10013583
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr7
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
18103937/18064314 (Hg38)
End
18103937/18064314 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-339/Upstream/10997269; hsa-mir-10399/Downstream/62906;
Nearest TSS
ENST00000635602/Upstream/36451; ENST00000455069/Downstream/22635;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/123395, chr7-CpG: 59/Downstream/21977
Nearby gene
PRPS1L1(-36451) ; HDAC9(+22635) ;
Upstream sequence
taaggcatgagaatcgcttgaaccccagaggcagaggttgccctgagccaagattgcaccattgaactcctgcctgggtgacagagcaagactctgCtaa
Downstream sequence
cagagctccccatggggtcagctgaggccttgttgtgacttcaccaaaagctcatcttctctctctgcctcaatccCTCTCTTTGTGGCTGGTCATTTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate