Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013586
Fusion event
HBV-SEMA3A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2099
Orient
+
Integrated sequence
CCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAAT| |GACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAA
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
Start
End
83651773/84022457 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10525/Upstream/8107188; hsa-mir-10399/Downstream/8181558;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/272620, chr7-CpG: 31/Downstream/917465
Upstream sequence
gggtcatagaatcattttttAACACATGGTAAACTTTATGGGATTTTTTGTCTTTGTTTTTTTTTTAAACCACAGGAAAAACTCTGtgaaattcttaaag
Downstream sequence
ATTGATTTCACTGTGGCCACTGAAACTTAATGACACAAATACAGATCTTTAATAATGTATACAGCGACCCTGGATATCTTTCCACGTGAAAATGTTATCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.