Basic Information
VIS ID
TVIS10013589
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1816
Orient
-
Integrated sequence
CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
34139271/34281753 (Hg38)
End
34139271/34281753 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/4324405; hsa-mir-10400/Downstream/6989295;
Nearest TSS
ENST00000518652/Upstream/32807; ENST00000519189/Downstream/502299;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/558671, chr8-CpG: 103/Downstream/953408
Nearby gene
DUSP26(-681832) ; UNC5D(+953704) ;
Nearest cancer related gene
DUSP26(OG, -681832) ; UNC5D(TSG, +953704) ;
Upstream sequence
attttcgaatcgatgttcatcagggatgttggcctaaaattttctttttttgttgtgtctctgccaggttttggtatcaggatgatgctggactcataaa
Downstream sequence
TTAAATATTAGGCAGCTACCTCTTGTCATTCTGGTCCGAGTGAGTGAAGAAAATACataaataaaaattaaataaaaGAAAAGGGCTAAAAATAAAAATC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate