Basic Information
VIS ID
TVIS10013603
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2164
Orient
+
Integrated sequence
CTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTT| |ATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTC
Host Sequence
Chromosome
chrX
Cytoband
p22.12
Reference genome
GRCh37/hg19
Start
21045682/21027564 (Hg38)
End
21045682/21027564 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-23c/Upstream/1010377; hsa-let-7f-2/Downstream/7467991;
Nearest TSS
ENST00000429181/Upstream/584238; ENST00000637785/Downstream/103932;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/758871, chrX-CpG: 163/Downstream/346153
Nearby gene
RPS6KA3(-760932) ; CNKSR2(+346854) ;
Upstream sequence
CTGAGTGCTCTGAATTATTTCATTTGATGTGAAAATCTTGGCAGAGACAACATTGTTCATTAATGTCCTGTAAGGCTGAGTTTGAGTAGTGAAGTAATAT
Downstream sequence
aggtgagtactaggactctcacctaaaatgctgtccttgtggcctagactgtctttcaagttcatttagctccccatagcaatttagctttaggtttgct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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