Basic Information
VIS ID
TVIS10013614
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1837
Orient
+
Integrated sequence
GGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCC| |TAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTAC
Host Sequence
Chromosome
chr10
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
88512738/86752981 (Hg38)
End
88512738/86752981 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D
Nearest miRNA
hsa-mir-1265/Upstream/488193; hsa-mir-107/Downstream/750900;
Nearest TSS
ENST00000439456/Upstream/34251; ENST00000480152/Downstream/3317;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/40804, chr10-CpG: 194/Downstream/2688
Nearby gene
LDB3(-16914) ; BMPR1A(+3658) ;
Nearest cancer related gene
BMPR1A(TSG, +3658) ;
Upstream sequence
ATTCTTCCTGCCTCAAGGCCTAGGAAAGATCAGGTTCTATGGTAAAGGGTGTACGGATAGTAGGGAAAGGAGGAATACAGAGGCCACGGACTAGGTAGGA
Downstream sequence
CCAAGTGAGAGCAGCAATATCCTCCATCATCTATCTTTCAATCATAGTAGCCAGTGCTTTGAGGCAAAGATAAATTAAAATGGAGCTAAGGGAGAAGGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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