TEAD4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10013627
Fusion event
HBV-TEAD4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2634
Orient
-
Integrated sequence
CACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATT| |GATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTC
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
3098348/2989182 (Hg38)
End
3098348/2989182 (Hg38)
Orient
+
Location type
Intronic
Target gene
TEAD4
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-181a-5p ; hsa-mir-512-5p
Nearest miRNA
hsa-mir-3649/Upstream/1328802; hsa-let-7i/Downstream/3974517;
Nearest TSS
ENST00000382841/Upstream/29238; ENST00000544666/Downstream/21862;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/28904, chr12-CpG: 91/Downstream/87663
Upstream sequence
ggtaaaacaacccagggcatgggattggcatgggaagtcgggaggcagtcctgtggaaccgagcccccaccctgtgggatctcctggcttcaagcaaccc
Downstream sequence
tcctgcctctcggcctcccaaagtgctgagattataggtatgagccaccatgcccagccCTGATTTTCTCAATGAGGCTCTTTGATtggtaaattctcta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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