Basic Information
VIS ID
TVIS10013636
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr15
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
24400964/24155817 (Hg38)
End
24400964/24155817 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105370732 ; LOC105370733
Nearest miRNA
hsa-mir-1268a/Upstream/593686; hsa-mir-10393/Downstream/1692930;
Nearest TSS
ENST00000557528/Upstream/180645; ENST00000568541/Downstream/14040;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/277532, chr15-CpG: 29/Downstream/271220
Nearby gene
NDN(-468514) ; PWRN2(+8962) ;
Upstream sequence
ttttagaataggtgtggtgtggtgctgaaaagaatgtatattctgttgatttggggtggagagttctgtagatgtctattatgtctgcttggtgcagagc
Downstream sequence
tgagttcaattcctggatatccttgttaactttctgtctcgtggatctgtctaatgttgacagtggggtgttagagtctcccattattattgtgtgggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate