Basic Information
VIS ID
TVIS10013648
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2932
Orient
+
Integrated sequence
GGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGC| |AAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGA
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
131852154/132516462 (Hg38)
End
131852154/132516462 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5C
Nearest miRNA
hsa-mir-10397/Upstream/150863; hsa-mir-103a-1/Downstream/911134;
Nearest TSS
ENST00000502646/Upstream/25664; ENST00000416135/Downstream/27060;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/19260, chr5-CpG: 43/Downstream/40410
Nearby gene
IRF1(-25689) ; IL5(+24982) ;
Nearest cancer related gene
IRF1(TSG, -25689) ;
Upstream sequence
CTCAAGGAAGGAGAAACAACGGGATCAAAGGCTCAAGGGAAGGGAAAGCACGAGCCGCGTACAGAAAGAAGGACTTCTCTTCGGTGTAGTCAGAAGGAAT
Downstream sequence
tctgcaccaagcagacctaatagacatctacagaactctccaccccaaatcaacagaatatacatttttttcaacaccacaccacacctattccaaaatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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