Basic Information
VIS ID
TVIS10013651
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr6
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
62231775/61521870 (Hg38)
End
62231775/61521870 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/4131658; hsa-mir-10524/Downstream/9855090;
Nearest TSS
ENST00000381078/Upstream/798722; ENST00000370659/Downstream/764357;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/3560320, chr6-CpG: 45/Downstream/764080
Nearby gene
KHDRBS2(+158090) ;
Upstream sequence
TTTTCCTTCTGAACGTGTTGGTGGGGGTAGTGGACTAGTTTTAATTAGAATCGTTTGGAGAACAGGAATCCAAGCACACGACCTAATATTCTCCTAGTTA
Downstream sequence
tctgcaccaagcagacataatagacatctacagaactctccaccccaaatcaacagaatatacattcgtttcagcaccacaccacacctattccaaaatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate