Basic Information
VIS ID
TVIS10013657
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2876
Orient
+
Integrated sequence
TTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAAT| |CCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAG
Host Sequence
Chromosome
chr9
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
41258292/42252809 (Hg38)
End
41258292/42252809 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/1018974; hsa-let-7a-1/Downstream/28557166;
Nearest TSS
ENST00000422679/Upstream/20998; ENST00000439824/Downstream/316501;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/123095, chr9-CpG: 37/Downstream/35545
Nearby gene
ZNF658(-466180) ; SPATA31A7(+62815) ;
Upstream sequence
tattcataggttctgaagattaggacttggacagctttaggagaccattattctgccaaccacCGTCCCTCTGTGCCTACACTTCAGGAAGATCTCGCTC
Downstream sequence
tgagttcaattcctggatatctttattaactttcagtctcgttgacagaaagtttctgtcaattcctggatatccttgttaactttctgtctcgttgaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate