Basic Information
VIS ID
TVIS10013662
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1803
Orient
-
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |CGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
107264832/105505074 (Hg38)
End
107264832/105505074 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1236669; hsa-mir-202/Downstream/5393016;
Nearest TSS
ENST00000439456/Upstream/346146; ENST00000424701/Downstream/314123;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/862020, chr10-CpG: 100/Downstream/1658948
Nearby gene
SORCS3(-239839) ; SORCS1(+1068589) ;
Upstream sequence
TACTAATGTTAAAGGGAAGCCAAGAAAGAAGTATGCATCATCGGTGTGATAAAAACAACTAGAGAAGCAATATAAAGAACTACTAAAAACATAGTGGCAA
Downstream sequence
CTGAGATCACCCTCAATGAATATCAGCCAAGAGATTAATTAATTGGACATCAGACAAAAGGCCACGTAGGAATTTTATGGAAACCTCTCTCTTTGTTGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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